Sustainable Health Lab

Engineering a Structural Transformation of the Healthcare Delivery System for Chronic Conditions


Journal Articles

  • [26] I. S. Khayal and A. E. Barnato, “What is in the palliative care ‘syringe’? A systems perspective,” Social Science and Medicine, 2022.
  • [25] I. S. Khayal and A. E. Barnato, “Development of dynamic health care delivery heatmaps for end-of-life cancer care: a cohort study,” BMJ Open, vol. 12, no. e056328, 2022.
  • [24] I. S. Khayal and A. M. Farid, “A dynamic system model for personalized healthcare delivery and managed individual health outcomes,” IEEE Access, vol. 9, pp. 138 267–138 282, 2021.
  • [23] A. E. Barnato and I. S. Khayal, “The power of specialty palliative care: moving towards a systems perspective,” The Lancet Haematology, vol. 8, no. 5, pp. e376–e381, 2021.
  • [22] I. S. Khayal and M. P. McGovern, “Implementing Patient-Centered Behavioral Health Integration into Primary Care using Model-Based Systems Engineering: A Case Study,” Systems Research and Behavioral Science, July 2020.
  • [21] A. M. Farid, M. Alshareef, P. S. Badhesha, C. Boccaletti, N. A. A. Cacho, C.-I. Carlier, A. Corriveau, I. Khayal, B. Liner, J. S. B. Martins, F. Rahimi, R. Rossetti, W. C. Schoonenberg, A. Stillwell, and Y. Wang, “Smart City Drivers & Challenges in Energy and Water System, Urban Mobility, Healthcare and Interdependent Infrastructure Systems, Part 1,” IEEE Potentials, vol. 40, no. 1, pp. 1–10, 2020.
  • [20] A. M. Farid, M. Alshareef, P. S. Badhesha, C. Boccaletti, N. A. A. Cacho, C.-I. Carlier, A. Corriveau, I. Khayal, B. Liner, J. S. B. Martins, F. Rahimi, R. Rossetti, W. C. Schoonenberg, A. Stillwell, and Y. Wang, “Smart City Drivers & Challenges in Energy and Water System, Urban Mobility, Healthcare and Interdependent Infrastructure Systems, Part 2,” IEEE Potentials, vol. 40, no. 1, pp. 11–16, 2020.
  • [19] G. Wasp, S. Alam, G. Brooks, I. Khayal, N. Kapadia, D. Carmichael, A. Austin, and A. Barnato, “Quality of end-of-life care for Medicare decedents at minority-serving cancer centers: A retrospective study,” Cancer Medicine, 2020. [Online]. Available: https://doi.org/10.1002/cam4.2752
  • [18] I. S. Khayal, “A Systems Thinking Approach to Designing Clinical Models and Healthcare Services,” Systems, vol. 7, no. 18, 2019.
  • [17] I. Khayal and A. Farid, “Architecting a System Model for Personalized Healthcare Delivery and Managed Individual Health Outcomes,” Complexity, vol. 2018, no. Article ID 8457231, p. 24, 2018.
  • [16] I. S. Khayal, W. Zhou, and J. Skinner, “Structuring and Visualizing Healthcare Claims Data Using Systems Architecture Methodology,” World academy of science, engineering and technology, vol. 11, no. 4, pp. 342–346, 2017.
  • [15] I. S. Khayal and A. M. Farid, “The Need for Systems Tools in the Practice of Clinical Medicine,” Systems Engineering, vol. 20, no. 1, pp. 3–20, Jan 2017 (Top 20 Most Downloaded Articles from 2017-2018). [Online]. Available: http://dx.doi.org/10.1002/sys.21374
  • [14] I. Khayal and A. M. Farid, “Axiomatic Design Based Human Resources Management for the Enterprise Transformation of the Abu Dhabi Healthcare Labor Pool,” Journal of Enterprise Transformation, vol. 5, no. 3, pp. 162–191, 2015.
  • [13] M. Butt, S. Quan, A. S. Pentland, and I. Khayal, “Gender Differences in Real-Home Sleep of Young and Older Couples,” Southwest Journal of Pulmonary and Critical Care, vol. 10, no. 1, pp. 289–299, 2015.
  • [12] M. Butt, T. B. M. J. Ouarda, S. F. Quan, A. S. Pentland, and I. Khayal, “Technologically sensed social exposure related to slow-wave sleep in healthy adults,” Sleep and Breathing, no. 19, pp. 255–261, 2015.
  • [11] T. Ouarda, C. Charron, K. N. Kumar, P. R. Marpu, H. Ghedira, A. Molini, and I. Khayal, “Evolution of the rainfall regime in the United Arab Emirates,” Journal of Hydrology, vol. 514, pp. 258–270, 2014.
  • [10] R. O. Oloritun, T. B. Ouarda, S. Moturu, A. Madan, A. S. Pentland, and I. Khayal, “Change in BMI Accurately Predicted by Social Exposure to Acquaintances,” PLOS One, vol. 8, no. 11, p. e79238, 2013.
  • [9] R. Oloritun, A. Madan, A. Pentland, and I. Khayal, “Identifying Close friendships in a Sensed Social Network,” Procedia-Social and Behavioral Sciences, vol. 79, pp. 18–26, 2013.
  • [8] N. Aharony, W. Pan, C. Ip, I. Khayal, and A. Pentland, “Social fMRI: Investigating and shaping social mechanisms in the real world,” Pervasive and Mobile Computing, vol. 7, no. 6, pp. 643–659, 2011. [Online]. Available: http://linkinghub.elsevier.com/retrieve/pii/S1574119211001246
  • [7] I. S. Khayal, S. R. Vandenberg, K. J. Smith, C. P. Cloyd, S. M. Chang, S. Cha, S. J. Nelson, and T. R. McKnight, “MRI apparent diffusion coefficient re  lects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas.” Neuro-oncology, vol. 13, no. 11, pp. 1192–1201, 2011.
  • [6] I. S. Khayal, M.-Y. C. Polley, L. Jalbert, A. Elkhaled, S. M. Chang, S. Cha, N. A. Butowski, and S. J. Nelson, “Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme,” Neurooncology, vol. 12, no. 9, pp. 908–916, 2010. [Online]. Available: http://www.ncbi.nlm.nih.gov/pubmed/20501631
  • [5] I. S. Khayal and S. J. Nelson, “Characterization of low-grade gliomas using RGB color maps derived from ADC histograms,” Journal of Magnetic Resonance Imaging, vol. 30, no. 1, pp. 209–213, Jul 2009. [Online]. Available: http://dx.doi.org/10.1002/jmri.21810
  • [4] I. S. Khayal, T. R. McKnight, C. McGue, S. Vandenberg, K. R. Lamborn, S. M. Chang, S. Cha, and S. J. Nelson, “Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas,” NMR in Biomedicine, vol. 22, no. 4, pp. 449–455, may 2009. [Online]. Available:http://dx.doi.org/10.1002/nbm.1357
  • [3] W. Bian, I. S. Khayal, J. M. Lupo, C. Mcgue, S. Vandenberg, K. R. Lamborn, and S. M. Chang, “Multiparametric Characterization of Grade 2 Glioma Subtypes Using Magnetic Resonance Spectroscopic, Perfusion and Diffusion Imaging,” Translational Oncology, vol. 2, no. 4, pp. 271–280, 2009.
  • [2] F. Crawford, I. Khayal, C. McGue, S. Saraswathy, A. Pirzkall, S. Cha, K. Lamborn, S. Chang,  M. Berger, and S. Nelson, “Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM,” Journal of Neuro-Oncology, vol. 91, no. 3, pp. 337–351, 2009. [Online]. Available: http://dx.doi.org/10.1007/s11060-008-9719-x
  • [1] I. S. Khayal, F. W. Crawford, S. Saraswathy, K. R. Lamborn, S. M. Chang, S. Cha, T. R. McKnight, and S. J. Nelson, “Relationship between choline and apparent diffusion coef  icient in patients with gliomas,” Journal of Magnetic Resonance Imaging, vol. 27, no. 4, pp. 718–725, Apr 2008. [Online]. Available: http://dx.doi.org/10.1002/jmri.21288

Conference Articles

  • [27] A. Mehdi and I. S. Khayal, “Modeling Chronic Care Delivery as a Dynamic System-of-Systems,” in Proceedings of the 17th Annual System of Systems Engineering Conference (SoSE-2022). Rochester, NY, USA: IEEE, June 2022.
  • [26] I. S. Khayal, “Healthcare Quality Improvement: The Need for a Macro-Systems Approach,” in Proceedings of the 16th Annual IEEE International Systems Conference. Montreal, Quebec, Canada: IEEE, April 2022.
  • [25] G. Mandell, M. Keating, and I. S. Khayal, “Development of a Visualization Tool for Healthcare Decision-Making using electronic medical records: A Systems Approach View a Patient Record,” in Proceedings of the 16th Annual IEEE International Systems Conference. Montreal, Quebec, Canada: IEEE, April 2022.
  • [24] L. C. L. Lit and I. S. Khayal, “Characterizing Emergent Behaviors in Twitter Telehealth Communication during the COVID-19 Pandemic,” in Proceedings of the 16th International Conference of System of Systems Engineering (SoSE-2021). Virtual: IEEE, June 2021.
  • [23] L. C. L. Lit and I. S. Khayal, “Understanding Twitter Telehealth Communication During the COVID-19 Pandemic using Hetero-Functional Graph Theory,” in Proceedings of the 6th IEEE International Smart Cities Conference (ISC2-2020). Virtual: IEEE, September 2020.
  • [22] I. S. Khayal, “Dynamic Modeling of Complex Healthcare Systems Using Big Data to Describe and Visualize Healthcare Utilization,” in Proceedings of the 14th Annual IEEE International Systems Conference (IEEE SysCon). Montreal, Quebec, Canada: IEEE, April 2020.
  • [21] I. S. Khayal, “Designing Technology and Healthcare Delivery Systems Using a Multistakeholder Systems Engineering Co-Design Methodology to Support Clinician and Patient Care Experiences,” in Proceedings of the 2019 IEEE International Symposium on Technology and Society (ISTAS). Medford, MA: IEEE, November 2019.
  • [20] K. Axel and I. S. Khayal, “Modeling ’Thriving Communities’ using a Systems Architecture to Improve Smart Cities Technology Approaches,” in Proceedings of the 4th IEEE International Smart Cities Conference (ISC2). Kansas City, MO: IEEE, September 2018.
  • [19] I. S. Khayal, “Modeling a Community as a System of Systems: A Methodology For Data Integration,” in Proceedings of the IEEE 13th System of Systems Engineering Conference (SoSE 2018), Paris, France, June 2018.
  • [18] I. S. Khayal and A. M. Farid, “Designing Patient-Oriented Healthcare Services as a System of Systems,” in Proceedings of the IEEE 13th System of Systems Engineering Conference (SoSE 2018), Paris, France, June 2018.
  • [17] I. S. Khayal and A. M. Farid, “A Dynamic Model for a Cyber-Physical Healthcare Delivery System with Human Agents,” in Proceedings of the 2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC2017), Intelligent Industrial System Special Issue, Banff, Canada, October 2017.
  • [16] I. S. Khayal and A. M. Farid, “Designing Smart Cities for Citizen Health & Well-being,” in Proceedings of the 2017 IEEE International Summer School on Smart Cities (IEEE S3C), Natal, Brazil, August 2017.
  • [15] I. S. Khayal and A. M. Farid, “An Architecture for a Cyber-Physical Healthcare Delivery System with Human Agents,” in Proceedings of the 2017 IEEE International Summer School on Smart Cities (IEEE S3C), Natal, Brazil, August 2017.
  • [14] I. S. Khayal, M. P. McGovern, M. L. Bruce, and S. J. Bartels, “Developing an Integrated Behavioral Health System Model using Engineering Design,” in Proceedings of the 2017 Institute of Industrial and Systems Engineering Annual Conference, Pittsburgh, PA, May 2017.
  • [13] I. S. Khayal, W. Zhou, and J. Skinner, “Structuring and Visualizing Healthcare Claims Data Using Systems Architecture,” in Proceedings of the 19th International Conference on Bioinformatics, Computational Biology and Biomedical Engineering, Boston, MA, April 2017.
  • [12] I. S. Khayal and A. M. Farid, “The Application of Model-Based Systems Engineering to the Practice of Clinical Medicine,” in Proceedings of the 2017 Annual IEEE International Systems Conference (SysCon), Montreal, Quebec, Canada, April 2017, pp. 1–6.
  • [11] A. Popoola, M. Butt, T. B. M. J. Ouarda, and I. Khayal, “Automatically Capturing Sleep and Social Factors to Understand Ramadan in the Real World,” in IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), Valencia, Spain, Jun 2014.
  • [10] R. Oloritun, A. Pentland, and I. Khayal, “Dynamics of Human Social Networks: People, Time, Relationships, and Places,” in Collaborative Innovation Networks Conference (COINs13). Chile: eprint arXiv:1308.1287, Aug 2013. [Online]. Available: http://adsabs.harvard.edu/abs/2013arXiv1308.1287O
  • [9] I. S. Khayal and A. M. Farid, “Axiomatic Design Based Volatility Assessment of the Abu Dhabi Healthcare Labor Market: Part II - Case Study,” in The Seventh International Conference on Axiomatic Design (ICAD2013), Worcester, MA, USA, Jun 2013, pp. 77–83.
  • [8] A. M. Farid and I. S. Khayal, “Axiomatic Design Based Volatility Assessment of the Abu Dhabi Healthcare Labor Market: Part I - Theory,” in The Seventh International Conference on Axiomatic Design (ICAD2013), Worcester, MA, USA, Jun 2013, pp. 71–76.
  • [7] M. Butt, S. T. Moturu, A. S. Pentland, and I. Khayal, “Automatically captured sociability and sleep quality in healthy adults,” in 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13). Osaka, Japan: Ieee, jul 2013, pp. 4662–4665. [Online]. Available: http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6610587
  • [6] R. Oloritun, A. Madan, A. Pentland, and I. Khayal, “Evolution of Social Encounters in Ad-Hoc Mobile Face-to-Face Interaction Networks,” in 2012 ASE International Conference on Social Informatics (SocialInformatics), vol. 0, Alexandria, VA, USA, dec 2012, pp. 192–198. [Online]. Available: http://doi.ieeecomputersociety.org/10.1109/SocialInformatics.2012.101
  • [5] R. O. Oloritun, A. Pentland, A. Madan, and I. Khayal, “Identifying Close friends interactions in Face-to-Face Networks,” in Applications of Social Network Analysis (ASNA2012), Zurich, Switzerland, Sep 2012, pp. 1–19.
  • [4] N. Aharony, W. Pan, C. Ip, I. Khayal, and A. Pentland, “The Social fMRI: Measuring, Understanding, and Designing Social Mechanisms in the Real World,” in 13th International Conference on Ubiquitous Computing (UbiComp 2011). Beijing, China: Massachusetts Institute of Technology, Sep 2011, pp. 445–454.
  • [3] S. T. Moturu, I. Khayal, N. Aharony, W. Pan, and A. S. Pentland, “Using Social Sensing to Understand the Links between Sleep, Mood, and Sociability,” in 2011 IEEE Third Intl Conference on Privacy Security Risk and Trust and 2011 IEEE Third Intl Conference on Social Computing, no. SocialCom. Boston, MA, USA: IEEE, Sep 2011, pp. 208–214.
  • [2] S. T. Moturu, I. Khayal, N. Aharony, W. Pan, and A. S. Pentland, “Sleep, mood and sociability in a healthy population,” in 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS’11), vol. 2011, Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139 USA. Boston, MA, USA: IEEE, Sep 2011, pp. 5267–5270. [Online]. Available: http://www.ncbi.nlm.nih.gov/pubmed/22255526
  • [1] J. Sairamesh, K. Argenbright, H. C. Simmons, R. Nemana, R. Rajagopal, I. Khayal, and P. Anderson, “Early Warning Methods for Improving Patient Care: Harnessing Insight from Raw Patient Notes,” in 3rd INFORMS Workshop on Data Mining and Health Informatics (DM-HI 2008), vol. 12, no. 10, Washington, D.C., USA, Oct 2008, p. s146. [Online]. Available: http://www.ncbi.nlm.nih.gov/pubmed/24091256

Patents

  • [5] I. Khayal, W. Naimark, and M. Palasis, “Multiple needle injection catheter and method of use of same,” United States Patent US7 442 187 B2, October 28, 2008.
  • [4] I. Khayal, W. Naimark, and M. Palasis, “Multiple needle injection catheter and method of use of same,” European Patent EP 1 841 486, October 10, 2007.
  • [3] T. Freyman, I. Khayal, and W. Naimark, “Apparatus and methods for delivering a bolus of therapeutic material,” United States Patent US 20 060 217 656, September 28, 2006.
  • [2] T. Freyman, I. Khayal, and W. Naimark, “Apparatus and methods for delivering a bolus of therapeutic material,” International Patent WO/2006/098 816, September 21, 2006.
  • [1] I. Khayal, W. Naimark, and M. Palasis, “Multiple needle injection catheter and method of use of same,” International Patent WO/2006/081 026, March 08, 2006.